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KMID : 0191120120270060668
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Journal of Korean Medical Science
2012 Volume.27 No. 6 p.668 ~ p.673
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Magnetoencephalography in Pediatric Lesional Epilepsy Surgery
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Kim Hun-Min
Lim Byung-Chan
Jeong Woo-rim
Kim June-Sic
Chae Jong-Hee
Kim Ki-Joong
Chung Chun-Kee
Hwang Yong-Seung
Hwang Hee
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Abstract
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This study was performed to assess the usefulness of magnetoencephalography (MEG) as a presurgical evaluation modality in Korean pediatric patients with lesional localization-related epilepsy. The medical records and MEG findings of 13 pediatric patients (6 boys and 7 girls) with localization-related epilepsy, who underwent epilepsy surgery at Seoul National University Children's Hospital, were retrospectively reviewed. The hemispheric concordance rate was 100% (13/13 patients). The lobar or regional concordance rate was 77% (10/13 patients). In most cases, the MEG spike sources were clustered in the proximity of the lesion, either at one side of the margin (nine patients) or around the lesion (one patient); clustered spike sources were distant from the lesion in one patient. Among the patients with clustered spike sources near the lesion, further extensions (three patients) and distal scatters (three patients) were also observed. MEG spike sources were well lateralized and localized even in two patients without focal epileptiform discharges in the interictal scalp electroencephalography. Ten patients (77%) achieved Engel class I postsurgical seizure outcome. It is suggested that MEG is a safe and useful presurgical evaluation modality in pediatric patients with lesion localization-related epilepsy.
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KEYWORD
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Magnetoencephalography, Epilepsy Surgery, Localization, Spike Source, Magnetic Source Imaging
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